Figure 3
From: HPV-transformed cells exhibit altered HMGB1-TLR4/MyD88-SARM1 signaling axis
HMGB1 is upregulated in epithelial rafts expressing HPV16 E7 and in squamous cell carcinomas. The expression of HMGB1 was determined by immunohistochemistry in organotypic cultures sections of (A) control; (B) HPV16 E6 expressing; (C) HPV16 E7 expressing and (D) with HPV16 E6E7 expressing keratinocytes and in squamous cell carcinomas (E,F) sample 1 and (G,H) sample 2. Note limit area between normal epithelium and high-grade lesion (E,G).
