Table 1 Genes from TLR-regulated pathway differentially expressed between cervical cancer cell lines and normal keratinocytes (>2-fold or <−2-fold change and p value ≤ 0.05). NS: non-significant.
From: HPV-transformed cells exhibit altered HMGB1-TLR4/MyD88-SARM1 signaling axis
Symbol | Description | HeLa | SiHa | C33A | |||
|---|---|---|---|---|---|---|---|
Fold regulation | p value | Fold regulation | p value | Fold regulation | p value | ||
A | Genes differentially expressed exclusively in HeLa or SiHa | ||||||
CCL2 | Chemokine (C-C motif) ligand 2 | 16.374 | 0.000 | NS | NS | NS | NS |
CD180 | CD180 molecule | 6.409 | 0.046 | NS | NS | NS | NS |
EIF2AK2 | Eukaryotic translation initiation factor 2-alpha kinase 2 | −7.835 | 0.03 | NS | NS | NS | NS |
IKBKB | Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | −2.651 | 0.005 | NS | NS | NS | NS |
MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | −2.822 | 0.000 | NS | NS | NS | NS |
PRKRA | Protein kinase, interferon-inducible double stranded RNA dependent activator | −2.373 | 0.017 | NS | NS | NS | NS |
TICAM2 | Toll-like receptor adaptor molecule 2 | −3.411 | 0.033 | NS | NS | NS | NS |
TLR1 | Toll-like receptor 1 | NS | NS | −16,329 | 0,043 | NS | NS |
TLR9 | Toll-like receptor 9 | −5.303 | 0.047 | NS | NS | NS | NS |
TRAF6 | TNF receptor-associated factor 6 | −6.007 | 0.029 | NS | NS | NS | NS |
B | Genes differentially expressed in HeLa and SiHa | ||||||
MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | −3.182 | 0.004 | −2.197 | 0.005 | NS | NS |
MAP4K4 | Mitogen-activated protein kinase kinase kinase kinase 4 | −4.902 | 0.005 | −2.732 | 0.009 | NS | NS |
REL | V-rel reticuloendotheliosis viral oncogene homolog (avian) | −4.287 | 0.001 | −2.989 | 0.002 | NS | NS |
TICAM1 | Toll-like receptor adaptor molecule 1 | −5.04 | 0.002 | −5.637 | 0.001 | NS | NS |
TLR10 | Toll-like receptor 10 | −8.694 | 0.002 | −4.741 | 0.005 | NS | NS |
TLR4 | Toll-like receptor 4 | 38.497 | 0.000 | 8.864 | 0.039 | NS | NS |
C | Genes differentially expressed in HeLa, SiHa and C33A | ||||||
IL12A | Interleukin 12A (natural killer cell stimulatory factor 1) | −5.205 | 0.001 | −2.65 | 0.002 | 3,725 | 0,000 |
IL1A | Interleukin 1, alpha | −820.296 | 0.003 | −478.054 | 0.003 | −2725,868 | 0,002 |
IL1B | Interleukin 1, beta | −2407.522 | 0.006 | −187.375 | 0.006 | −2584,793 | 0,005 |
IRAK4 | Interleukin-1 receptor-associated kinase 4 | −5.897 | 0.01 | −2.99 | 0.046 | 4,039 | 0,000 |
LY96 | Lymphocyte antigen 96 | −739.292 | 0.032 | −99.892 | 0.033 | −18,885 | 0,038 |
PELI1 | Pellino homolog 1 (Drosophila) | −10.954 | 0.004 | −6.118 | 0.005 | −2,967 | 0,013 |
PTGS2 | Prostaglandin-endoperoxide synthase 2 | −174.047 | 0.000 | −19.096 | 0.001 | −1356,650 | 0,000 |
RIPK2 | Receptor-interacting serine-threonine kinase 2 | −5.439 | 0.002 | −2.578 | 0.004 | 2,441 | 0,000 |
SARM1 | Sterile alpha and TIR motif containing 1 | 6.948 | 0.004 | 116.056 | 0.022 | 18,262 | 0,000 |
TLR2 | Toll-like receptor 2 | −560.278 | 0.006 | −55.568 | 0.006 | −77,127 | 0,006 |
TLR3 | Toll-like receptor 3 | −12.409 | 0.002 | −4.412 | 0.005 | −2,107 | 0,025 |
TLR5 | Toll-like receptor 5 | −27.538 | 0.011 | −11.953 | 0.013 | −3,107 | 0,045 |
