Figure 5

Analgesic effects of duloxetine on muscle pressure pain threshold (MPPT) in chronic post-cast pain rats. Duloxetine was orally administered before the muscle pressure test at 1 (A,B) and 3 (C,D) weeks after cast removal. Bars represent mean values ± standard error of the mean (n = 5–6). ^###P < 0.001 relative to the untreated group (Student’s t-test). ^**P < 0.01 relative to the vehicle-treated group (one-way ANOVA with Dunnett’s multiple comparison test).