Figure 6
Analgesic effects of repeated administration of duloxetine on muscle pressure pain threshold (MPPT) in chronic post-cast pain rats. (A) Schematic illustration of experimental protocol for (B,C). Duloxetine was orally administered before the muscle pressure test at 3 hours, 1 day, and 2 days after cast removal. Time-course changes in ipsilateral calf MPPT (B) and contralateral calf MPPT (C) after cast removal. Bars represent mean values ± standard error of the mean (n = 6). *P < 0.05, **P < 0.01, and ***P < 0.001 relative to the vehicle-treated group (Student’s t-test).
