Figure 1 | Scientific Reports

Figure 1

From: Enhanced protection of the renal vascular endothelium improves early outcome in kidney transplantation: Preclinical investigations in pig and mouse

Figure 1

The physiological role of the vascular endothelium and the proposed mechanism of the heparin conjugate, CHC. Healthy EC actively inhibit or regulate the activation and recruitment of platelets and leukocytes (A). Activated or dysfunctional EC recruit leukocytes and activated platelets during a process termed thromboinflammation (B). Thromboinflammation negatively effects blood flow, and during kidney transplantation it can reduce early graft function. We hypothesized that coating the renal endothelium with the heparin conjugate (green structures in C) prior to transplantation would reduce the impact of the activated endothelium on the blood compartment (C). The result would thus be a reduction in thromboinflammation and subsequently, an increase in the early function of the kidney.

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