Figure 2 | Scientific Reports

Figure 2

From: Enhanced release of acid sphingomyelinase-enriched exosomes generates a lipidomics signature in CSF of Multiple Sclerosis patients

Figure 2

(A) ASMase expression in pooled CSF from MuS patients vs pooled OND CSF (divided in central and peripheral disease). The histograms show the mean normalized OD of the ASMase band (57KDa) relative to the OD of the proASMase band (75KDa). Error bars show the standard error of the mean from three independent pools of each disease condition. The image of WB is cropped from the same gel reported in Fig. S7. (B) Enzymatic activity of ASMase in CSF of the same pooled samples by using fluorescent SM-FLBODIPY (reaction reported in the scheme) incubated with CSF and analyzed by HPLC-FLD. C_OND and P_OND mean Other Central and Peripheral Neurological Diseases, respectively. **Means p < 0.001 obtained by Mann-Whitney test.

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