Figure 3 | Scientific Reports

Figure 3

From: Enhanced release of acid sphingomyelinase-enriched exosomes generates a lipidomics signature in CSF of Multiple Sclerosis patients

Figure 3

(A) CSF ASMase activity calculated in 87 MuS CSF and 57 OND patients divided into 34 C_OND and 23 P_OND. (B) Comparison of CSF ASMase activity in MuS patients and a sub-group of inflammatory neurological diseases, obtained by the exclusion of non-inflammatory diseases from the OND data set. (C) Receiver Operating Characteristic (ROC) curve for ASMase activity in MuS patients vs P_OND obtaining (p < 0.0001) an Area Under the Curve (AUC) of 0.88, sensitivity = 78.16% and specificity = 86.96% for a cutoff = 0.34. (D) ROC curve for ASMase activity in MuS patients vs C_OND obtaining (p < 0.001) AUC = 0.68, sensitivity = 56.32% and specificity = 70.59% for a cutoff = 0.43. *Means p < 0.05, **means p < 0.001 and ***means p < 0.0001 of Kruskal-Wallis test with Dunn’s Multiple Comparison post-test.

Back to article page