Figure 6

Subnetworks created by ClusterMark® to establish the interaction between proteins identified with differential expression in the 50 mgF/L group in relation to the control group. The color of the nodes indicates the differential expression of the respective named protein with its access code. The dark red and dark green nodes indicate proteins unique to the control and 50 mgF/L groups, respectively. The nodes in gray indicate the interaction proteins that are offered by CYTOSCAPE®, which were not identified in the present study and the light red and light green nodes indicate downregulation and upregulation, respectively. In (A), the access numbers in the gray nodes correspond to: PTEN induced putative kinase 1 (Predicted) (D3Z9M9), Mitogen-activated protein kinase 3 (P21708), T-complex protein 1 subunit beta (Q5XIM9), Gap junction alpha-1 protein (P08050), Cartilage oligomeric matrix protein (P35444), Acid ceramidase (Q6P7S1), Integrin alpha-7 (Q63258), Stress-70 protein, mitochondrial (P48721), Solute carrier family 2, facilitated glucose transporter member 4 (P19357), Histone H3.1 (Q6LED0), Heterogeneous nuclear ribonucleoprotein K (P61980), Ankyrin-3 (O70511), Plectin (P30427) and Ankyrin-3 (O70511-7). The access numbers of the unique proteins of the control (dark red nodes) correspond to: Malate dehydrogenase, cytoplasmic (O88989), 40 S ribosomal protein S10 (P63326), Eukaryotic initiation factor 4A-II (Q5RKI1) and Vinculin (P85972). The accession numbers of the unique 50 mgF/L (dark green nodes) proteins correspond to: Tektin-2 (Q6AYM2), Mitochondrial fission 1 protein (P84817) and Paralemmin-1 (Q920Q0). The access numbers of the downregulated proteins (light red nodes) correspond to: Histone H2A type 2-A (P0CC09) and Histone H2A.Z (P0C0S7). The accession numbers of the upregulated proteins (light green nodes) correspond to: Hemoglobin subunit beta-1 (P02091) and Hemoglobin subunit alpha-1/2 (P01946). In (B), the access numbers in the gray nodes correspond to: Polyubiquitin-C (Q63429), Protein Svil (D3ZEZ9) e Glucocorticoid receptor (P06536). The access numbers of the unique proteins of the control (dark red nodes) correspond to: Heat shock protein 75 kDa, mitochondrial (Q5XHZ0), Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (P10888) and NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial (P19234). The accession numbers of the single 50 mgF/L (dark green nodes) proteins correspond to: Mitogen-activated protein kinase 4 (Q63454), Synaptic vesicle membrane protein VAT-1 homolog (Q3MIE4), ATP-dependent 6-phosphofructokinase, liver type (P30835), Tissue alpha-L-fucosidase (P17164) and Peroxiredoxin-6 (O35244). The access numbers of the downregulated proteins (light red nodes) correspond to: ATP synthase subunit beta, mitochondrial (P10719) and e Histone H2A type 1-F (Q64598). The accession numbers of the upregulated proteins (light green nodes) correspond to: Tubulin beta-2A chain (P85108).