Table 1 Quantitative results of the morphometric tibia bone parameters for BALB/cJ P2X7R−/− and littermate BALB/cJ P2X7R+/+ at 4 months of age.

From: P2X7 receptor regulates osteoclast function and bone loss in a mouse model of osteoporosis

 

P2X7R+/+ N = 9

P2X7R−/− N = 7

Mean difference

p-value

Ct.TMD (g/cm3)

1.506 ± 0.01

1.453 ± 0.02

↓

0.0178

Ct.BV (mm3)

0.8175 ± 0.014

0.8727 ± 0.036

↑

0.0418a

Ct.Th (mm)

181.6 ± 1.5

179.4 ± 6.1

 

0.6932

TMD (g/cm3)

1.262 ± 0.008

1.258 ± 0.011

 

0.7611

BV/TV

8.595 ± 0.427

9.422 ± 0.823

 

0.3574

Tb.Th (mm)

0.0500 ± 0.0005

0.0512 ± 0.0010

 

0.2865

Tb.N (1/mm)

1.717 ± 0.0836

1.835 ± 0.1424

 

0.4660

Tb.Pf (1/mm)

24.36 ± 0.80

24.11 ± 1.50

 

0.8787

Tb.Sp (mm)

0.3243 ± 0.0131

0.2993 ± 0.0213

 

0.3114

SMI

2.122 ± 0.047

2.129 ± 0.073

 

0.9360

Endo. N.Ob/B Pm

29.34 ± 5.7

15.32 ± 3.4

↓

0.009b

Endo Ob.Pm/B Pm

0.3213 ± 0.041

0.2393 ± 0.056

 

0.122b

Endo. N.Oc/B Pm

0.1603 ± 0.1035

0.5692 ± 0.0925

↑

0.015b

Endo Oc.Pm/B Pm

0.004975 ± 0.0031

0.01904 ± 0.0046

↑

0.035b

Tb. N.Ob/B Pm

3.0497 ± 0.9986

1.2951 ± 0.5129

 

0.098b

Tb Ob.Pm/B Pm

0.0553 ± 0.01989

0.0153 ± 0.00457

↓

0.041b

Tb. N.Oc/B Pm

2.9266 ± 1.032

6.6056 ± 0.5384

↑

<0.001b

Tb Oc.Pm/B Pm

0.0807 ± 0.02881

0.1705 ± 0.01732

↑

0.003b

N.Ad/Ma.Ar (mm2)

12.93 ± 8.816

18.27 ± 5.508

 

0.505b

  1. Values are mean ± SEM.
  2. Ct. TMD: Cortical tissue mineral density, Ct.BV: Cortical bone volume, Ct.Th: Cortical thickness, TMD: Tissue mineral density, BV/TV: Bone volume fraction, Tb.Th: Trabecular thickness, Tb.N: Trabecular number, Tb.Pf: Trabecular pattern factor, Tb. Sp: Trabecular Separation, SMI: Structure Model Index, Endo. N.Ob/B Pm: Osteoblast number per mm endocortical bone surface, Endo Ob.Pm/B Pm: Percentage endocortical surface occupied by osteoblasts, Endo. N.Oc/B Pm: Osteoclast number per mm endocortical bone surface, Endo Oc.Pm/B Pm: Percentage endocortical surface occupied by osteoclasts, Tb. N.Ob/B Pm: Osteoblast number per mm trabecular bone surface, Tb Ob.Pm/B Pm: Percentage trabecular surface occupied by osteoblasts, Tb. N.Oc/B Pm: Osteoclast number per mm trabecular bone surface, Tb Oc.Pm/B Pm: Percentage trabecular surface occupied by osteoclasts, N.Ad/ Ma.Ar (mm2): The number of adipocyte per mm2 bone marrow area. Data was analysed using either an unpaired t-test or aMann-Whitney test, or bUnivariate Analysis of Variance as appropriate for the experimental design and data set.
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