Table 2 SSE15206 overcomes multidrug resistance.

From: Identification and characterization of SSE15206, a microtubule depolymerizing agent that overcomes multidrug resistance

Cell line

Compound GI50

Paclitaxel (nM)

SSE15206 (nM)

Vinblastine (nM)

Vincristine (nM)

Etoposide (μM)

KB-3-1 (Control)

0.85 ± 0.16 (n = 3)

378.33 ± 0.92 (n = 3)

0.89 ± 0.14 (n = 3)

ND

0.74 ± 0.025 (n = 2)

KB-V1 (MDR-1)

896.33 ± 65.62 (n = 3)

354 ± 89.82 (n = 3)

79.3 ± 103 (n = 3)

ND

16.07 ± 12.18 (n = 2)

Fold Resistance

1054

0.94

89

 

21.72

A2780 (Control)

2.03 ± 0.84 (n = 2)

145.65 ± 0.64 (n = 2)

ND

6.04 ± 1.59 (n = 4)

0.65 (n = 1)

A2780-Pac-Res

204.65 ± 3.18 (n = 2)

224.45 ± 21.29 (n = 2)

ND

95.1 ± 24.81 (n = 4)

36.17 (n = 1)

Fold Resistance

101

1.54

 

15.7

56

HCT116 (Control)

1.01 ± 0.026 (n = 3)

261.63 ± 143.22 (n = 3)

ND

ND

ND

HCT116-Pac-Res

178.67 ± 65.17 (n = 3)

316.53 ± 19.69 (n = 3)

ND

ND

ND

Fold Resistance

176

1.2

   
  1. Efficacy of different chemotherapeutic drugs and SSE15206 in different drug-resistant cell lines and their parental controls is shown. The GI50 values (in nM or μM) are presented as mean of (n) independent experiments ± standard deviation. The resistance of cell lines to various drugs is presented as fold-resistance compared to the parental control. ND = not determined.
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