Table 2 Bone Structural Parameters from MGP mice by sex.
Sex | Males | Females | ||||||
|---|---|---|---|---|---|---|---|---|
Genotype | WT | KO | WT | KO | ||||
Mean (SD) | Mean (SD) | Mean (SD) | Mean (SD) | |||||
Diet | Control | High Fat | Control | High Fat | Control | High Fat | Control | High Fat |
(n = 8) | (n = 14) | (n = 8) | (n = 7) | (n = 11) | (n = 11) | (n = 9) | (n = 6) | |
Femur | ||||||||
Length/mm | 10.7 (0.6)ab | 11.5 (0.7)b | 9.7 (0.5)c | 10.6 (0.7)ac | 10.5 (0.6)a | 11.5 (0.9)b | 9.5 (0.6)c | 10.6 (0.6)ab |
BV/mm3 | 5.6 (1.8)ab | 8.2 (3.1)b | 4.4 (1.2)a | 5.0 (1.6)a | 5.6 (1.6)a | 9.1 (3.4)b | 3.8 (1.3)a | 5.1 (2.4)a |
BvTv | 24 (13)a | 40 (14)b | 9 (6)a | 15 (6)a | 18 (11)a | 38 (14)b | 6 (3)a | 21 (12)a |
BsBv | 34 (22)ab | 22 (5)b | 51 (23)a | 42 (23)ab | 42 (26)ab | 22 (6)b | 57 (32)a | 28 (5)ab |
TbTh/mm | 0.15 (0.05)ab | 0.22 (0.07)b | 0.11 (0.03)a | 0.13 (0.05)a | 0.14 (0.05)a | 0.21 (0.05)b | 0.10 (0.03)a | 0.16 (0.02)ab |
TbSp/mm | 0.60 (0.20)a | 0.45 (0.18)b | 0.70 (0.07)a | 0.63 (0.12)ab | 0.65 (0.18)a | 0.46 (0.16)b | 0.73 (0.08)a | 0.62 (0.19)ab |
SMI | 2.3 (0.4)a | 2.2 (0.6)b | 2.9 (0.6)a | 2.5 (0.5)ab | 2.6 (0.4) | 2.1 (0.7) | 2.7 (0.4) | 2.6 (0.4) |
TbPF/mm−1 | 9 (4)ab | 5 (4)b | 20 (7)c | 13 (5)ac | 15 (11)a | 6 (6)b | 21 (3)a | 11 (6)ab |
ConnD/mm−3 | 71 (22) | 82 (19) | 94 (65) | 91 (55) | 98 (64) | 77 (12) | 61 (63) | 69 (24) |
Cortical BV/mm3 | 0.9 (0.3)a | 1.4 (0.5)b | 0.6 (0.1)a | 0.8 (0.2)a | 0.9 (0.1)a 12 | 1.5 (0.4)b 1 | 0.5 (0.1)c 1 | 0.8 (0.2)ac 2 ˅ |
Cortical Th/mm | 0.13 (0.02)a | 0.17 (0.04)b | 0.11 (0.01)a | 0.12 (0.02)a | 0.14 (0.01)a 1 | 0.18 (0.04)b 1 | 0.10 (0.01)c 1 | 0.12 (0.02)ac 2˅ |
MidD/mm | 1.11 (0.07)ac | 1.19 (0.05)b | 1.07 (0.07)c | 1.17 (0.05)ab | 1.09 (0.06)a | 1.21 (0.08)b | 1.06 (0.06)a | 1.13 (0.05)ab |
MidWT/mm | 0.13 (0.02)ab | 0.14 (0.02)b | 0.11 (0.01)a | 0.12 (0.01)a | 0.13 (0.01)ab 1 | 0.15 (0.02)b 12 | 0.11 (0.01)c 12 | 0.12 (0.02)ac 2˅ |
Tibia | ||||||||
Length/mm | 11.1 (0.6)ab | 11.7 (0.6)a | 10.6 (0.3)b | 10.9 (0.8)ab | 11.2 (0.3)ab | 11.7 (0.7)a | 10.3 (0.6)b | 10.9 (0.4)ab |
BV/mm3 | 5.7 (0.8)a | 8.3 (1.0)b | 4.1 (0.5)c | 4.9 (1.1)ac | 5.6 (0.6)a 12 | 8.7 (1.2)b 1 | 3.7 (0.9)c 12 | 4.7 (0.6)ac 2˅ |
BvTv | 24 (6) | 25 (5) | 22 (3) | 26 (9) | 21 (2) | 29 (9) | 22 (7) | 23 (6) |
BsBv | 30 (4) | 33 (5) | 31 (3) | 31 (6) | 32 (3) | 31 (4) | 32 (7) | 30 (3) |
TbTh/mm | 0.15 (0.02) | 0.15 (0.02) | 0.15 (0.01) | 0.15 (0.02) | 0.15 (0.02) | 0.16 (0.02) | 0.14 (0.03) | 0.15 (0.02) |
TbSp/mm | 0.50 (0.08) | 0.39 (0.07) | 0.51 (0.04) | 0.43 (0.07) | 0.48 (0.04)a 12 | 0.36 (0.07)b 1 | 0.49 (0.05)a 1 | 0.53 (0.07)a 2^ |
SMI | 2.6 (0.2) | 2.9 (0.1) | 2.6 (0.2) | 2.5 (0.4) | 2.9 (0.4)a | 2.7 (0.4)ab | 2.3 (0.1)b | 2.6 (0.3)ab |
TbPF/mm−1 | 11 (2) | 13 (3) | 11 (1) | 11 (5) | 13 (2) | 11 (4) | 10 (2) | 11 (3) |
ConnD/mm-3 | 70 (9)a | 138 (53)b | 77 (10)a | 96 (12)ab | 80 (22) | 113 (19) | 77 (15) | 87 (9) |
Cortical BV/mm3 | 1.0 (0.1)a | 1.4 (0.1)b | 0.7 (0.1)c | 0.8 (0.2)ac | 1.0 (0.1)a 1 | 1.5 (0.2)b 1 | 0.6 (0.1)c 1 | 0.8 (0.1)c 2˅ |
Cortical Th/mm | 0.15 (0.02)a | 0.19 (0.01)b | 0.12 (0.01)c | 0.13 (0.02)ac | 0.15 (0.01)a 1 | 0.20 (0.01)b 1 | 0.11 (0.01)c 12 | 0.13 (0.01)c 2˅ |
Vertebra | ||||||||
Length/mm | 2.1 (0.2)ab | 2.3 (0.2)a | 1.8 (0.1)b | 2.2 (0.3)a | 2.1 (0.2)a | 2.4 (0.3)b | 1.8 (0.1)c | 2.2 (0.2)ab |
BV/mm3 | 4.1 (1.0)ab | 5.3 (1.5)a | 3.1 (0.6)b | 3.9 (0.8)ab | 3.9 (0.9)a 1 | 5.8 (1.8)b 1 | 2.8 (0.6)a 2^ | 4.1 (1.1)ab 12 |
BvTv | 53 (6) | 51 (16) | 53 (9) | 46 (10) | 48 (8) | 48 (9) | 51 (10) | 42 (15) |
BsBv | 29 (3) | 28 (7) | 30 (4) | 33 (6) | 31 (3) | 29 (5) | 30 (5) | 34 (8) |
TbTh/mm | 0.13 (0.01) | 0.14 (0.03) | 0.13 (0.01) | 0.12 (0.02) | 0.12 (0.01) | 0.14 (0.02) | 0.13 (0.02) | 0.12 (0.03) |
TbSp/mm | 0.16 (0.01) | 0.17 (0.03) | 0.16 (0.02) | 0.17 (0.01) | 0.17 (0.02) | 0.18 (0.02) | 0.17 (0.02) | 0.18 (0.02) |
SMI | 1.2 (0.3) | 1.1 (0.6) | 1.2 (0.3) | 1.4 (0.5) | 1.4 (0.3) | 1.3 (0.4) | 1.4 (0.5) | 1.5 (0.7) |
TbPF/mm−1 | 3 (2) | 3 (4) | 3 (2) | 5 (4) | 5 (2) | 4 (3) | 5 (3) | 6 (6) |
ConnD/mm−3 | 89 (19) | 70 (19) | 90 (17) | 93 (20) | 83 (17) | 71 (18) | 88 (31) | 81 (25) |