Figure 1

Multivariate (Model 2) hazard ratios HRs and 95% confidence interval for CVD associated with tertiles of red blood cell parameters (panel A), white blood cell parameters (panel B) and platelet parameters (panel C), n = 14,362, EPIC-NL. HRs adjusted for age, smoking status and intensity (7 categories), body mass index (BMI, continuous), Waist-to-hip ratio (WHR, continuous), physical activity level (Cambridge index, 4 categories), educational level (low, medium, high), alcohol intake (non drinker, occasional drinker, frequent drinker), systolic blood pressure, HDL cholesterol and diabetes. Stratified by sex and cohort centre. Age is the underlying time variable. Exit age is age at first outcome of interest or censoring. Cut-off points for tertiles: Men: RBC 4.9, 5.2; Haematocrit 0.45, 0.47; MCV 89.7, 92.7; RDW 12, 12.4; WBC 5.7, 7.0; Lymphocyte 1.7, 2.1; Monocyte 0.5, 0.6; Neutrophils 3.1, 4.1; Platelets 212, 253; Plateletcrit 0.19, 0.23; MPV 8.6, 9.3; PDW 15.6, 15.9; Women: RBC 4.3, 4.6; Haematocrit 0.39,0.42; MCV 89.3, 92.5; RDW 11.9, 12.4; WBC 5.7, 7.1; Lymphocyte 1.7, 2.1; Monocyte 0.4, 0.5; Neutrophils 3.3, 4.4; Platelets 233, 279; Plateletcrit 0.21, 0.25; MPV 8.7, 9.4; PDW 15.5, 15.8.