Table 3 Multivariate (Model 2^a) hazard ratios per tertile of red blood cell and platelet distribution width, separately for men and women, n = 14,362, EPIC-NL.

	Tertile	Men				Women			P trend	p-interaction
	Tertile	N total	N cases	HR (95%CI)	P trend	N total	N cases	HR (95%CI)	P trend	p-interaction
CVD
RDW (%)^d	T1	1328	73	1 (ref)	0.07	3081	161	1 (ref)	0.26	0.0004
	T2	1485	123	1.22 (0.91; 1.63)		4051	245	0.97 (0.79; 1.19)
	T3	1253	151	1.33 (0.99; 1.79)		3164	239	1.16 (0.93; 1.44)
PDW (%)^f	T1	1336	86	1 (ref)	0.14	3263	204	1 (ref)	0.09	0.007
	T2	1389	131	1.30 (0.99; 1.72)		3628	213	0.78 (0.64; 0.96)
	T3	1341	130	1.28 (0.96; 1.71)		3405	228	0.80 (0.65; 0.99)
CHD
RDW (%)^d	T1	1328	45	1 (ref)	0.10	3081	91	1 (ref)	0.32	0.005
	T2	1485	89	1.45 (0.99; 2.10)		4051	131	0.92 (0.70; 1.21)
	T3	1253	95	1.33 (0.90; 1.96)		3164	138	1.11 (0.84; 1.48)
PDW (%)^f	T1	1336	51	1 (ref)	0.07	3263	131	1 (ref)	0.002	0.0003
	T2	1389	90	1.48 (1.04; 2.12)		3628	115	0.67 (0.52; 0.87)
	T3	1341	88	1.44 (0.99; 2.09)		3405	114	0.63 (0.48; 0.82)

^aHRs adjusted for age, smoking status and intensity (7 categories), body mass index (BMI, continuous), Waist-to-hip ratio (WHR, continuous), physical activity level (Cambridge index, 4 categories), educational level (low, medium, high), alcohol intake (non drinker, occasional drinker, frequent drinker), systolic blood pressure, HDL cholesterol and diabetes. Stratified by sex and cohort centre. Age is the underlying time variable. Exit age is age at first outcome of interest or censoring. Abbreviations: CVD, cardiovascular disease; CHD, coronary heart disease.

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