Table 4 Change in discrimination (C-statistic) and reclassification for the evaluation of incremental value of selected elements of the complete blood count over the SCORE risk prediction model.

	C-statistic	95% CI		p-value difference	Categorical NRI	95% CI		p-value	IDI	95% CI		p-value
Model 0 “SCORE”^a	0.7324	0.7168	0.748		Ref				Ref
Model 0 + MCV	0.7330	0.7174	0.7486	0.25	0.51%	−0.82%	1.84%	0.45	0.0005	−0.0001	0.0010	0.08
Model 0 + RDW	0.7325	0.7168	0.7481	0.41	0.00%	−0.34%	0.34%	1.00	0.0000	0.0000	0.0001	0.15
Model 0 + WBC	0.7345	0.719	0.7501	0.14	0.50%	−1.70%	2.71%	0.65	0.0034	0.0018	0.0051	<0.001
Model 0 + Lymphocytes	0.7348	0.7193	0.7503	0.02	1.08%	−0.82%	2.99%	0.27	0.0017	0.0001	0.0033	0.03
Model 0 + Monocytes	0.7346	0.7191	0.7501	0.14	1.24%	−0.80%	3.28%	0.23	0.0024	0.0010	0.0038	0.001
Model 0 + Neutrophils	0.7329	0.7173	0.7486	0.63	−0.72%	−2.63%	1.19%	0.46	0.0020	0.0009	0.0032	0.001
Model 0 + Platelet count	0.7329	0.7173	0.7485	0.52	−0.43%	−2.05%	1.19%	0.60	0.0005	−0.0002	0.0011	0.20
Model 0 + PDW	0.7327	0.7171	0.7483	0.32	−0.17%	−1.21%	0.87%	0.76	0.0000	−0.0002	0.0002	0.99

^aModel 0 includes age, smoking status (binary), total- to HDL-cholesterol ratio, systolic blood pressure and is stratified by sex and cohort. The primary time variable is follow-up time. Abbreviations: NRI, net reclassification improvement, categorical (three 10-year risk categories: 0–5%, 5–10%, >10%); IDI, integrated discrimination improvement.

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