Table 3 Circumferential tensile properties of adventitia vessels cultured for 1 day, 1 week and 2 week periods.

From: Self-assembled Collagen-Fibrin Hydrogel Reinforces Tissue Engineered Adventitia Vessels Seeded with Human Fibroblasts

Hydrogel vessel Group

 

Tensile Properties (kPa)

Elastic Modulus (E)

Ultimate Tensile Strength (UTS)

Failure Strength (FS)

1 d

Fibrin only (n = 3)

641 ± 114

108 ± 15.0

11.6 ± 5.24c,d,e,f

0.7 mg/ml COL (n = 3)

856 ± 99.2c,d

119 ± 20.2

9.75 ± 4.45c,d,e,f

1 wk

Fibrin only (n = 5)

472 ± 94.1b,f

105 ± 12.4

49.9 ± 28.4a

0.7 mg/ml COL (n = 5)

536 ± 119b,f

103 ± 28.9

58.9 ± 9.62a

2 wk

Fibrin only (n = 5)

576 ± 147b,f

103 ± 27.4

57.8 ± 18.0a

0.7 mg/ml COL (n = 5)

771 ± 203c,d,e

120 ± 23.6

41.2 ± 6.41a

  1. All groups used human fibroblasts for seeding of the 6-ring stack vessels and cytokine stimulation with TGF-β and ascorbic acid. aDenotes statistical significance to fibrin only – 1 d (p ≤ 0.05). bDenotes statistical significance to 0.7 mg/ml COL – 1 d (E: p ≤ 0.01; FS: p ≤ 0.05). cDenotes statistical significance to fibrin only – 1 wk (p ≤ 0.05). dDenotes statistical significance to 0.7 mg/ml COL – 1 wk (E: p ≤ 0.05; FS: p ≤ 0.001). eDenotes statistical significance to fibrin only – 2 wk (E: p ≤ 0.05; FS: p ≤ 0.001). fDenotes statistical significance to fibrin only – 2 wk (p ≤ 0.05).
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