Figure 7 | Scientific Reports

Figure 7

From: Pancreatic alpha cells in diabetic rats express active GLP-1 receptor: Endosomal co-localization of GLP-1/GLP-1R complex functioning through intra-islet paracrine mechanism

Figure 7

Isolated pancreatic perfusion profile of diabetic rats stimulated by EX4 and IBMX. (a) 11-week-old F344/Jcl rat (BW 276 g, FBS 110 mg/dl). 1–20 min, 5.5 mM glucose; 21–60 min, 5,5 mM glucose and 10 nM Exendin-4. (b) 12-week-old F344/Jcl rat treated with STZ (BW 194 g, FBS 291 mg/dl). 1–20 min, 5.5 mM glucose; 21–41 min, 5,5 mM glucose and 10 nM Exendin-4; 41–60 min, 5,5 mM glucose and 2.0 mM IBMX. (c) 10-week-old Wistar rat treated with STZ (BW 302 g, BS 472 mg/dl). 1–20 min, 5.5 mM glucose; 21–60 min, 5.5 mM glucose and 10 nM EX4; 61–80 min, 5.5 mM glucose and 2 mM IBMX. (d) 25-week-old GK rat (BW 370 g, BS 220 mg/dl). 1–20 min, 5.5 mM glucose; 21–60 min, 5.5 mM glucose and 10 nM EX4; 61–80 min, 5.5 mM glucose and 2 mM IBMX.

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