Figure 4
From: Impact of Reduced Cerebellar EAAT Expression on Purkinje Cell Firing Pattern of NPC1-deficient Mice
Chloride-dependent effect of TBOA on Purkinje cell activity pattern. (A) Example traces of TBOA induced change of activity pattern from tonic firing to inactive and (B) tonic to burst firing. (C) Applying TBOA, a significantly reduced number of PCs in NPC1+/+ mice changed their activity pattern using different Cl−[i] (Low Cl−[i]: N = 3, n = 10; high Cl−[i]: N = 7, n = 16). No such effect was observed in NPC1−/− mice (Low Cl−[i]: N = 5, n = 12; high Cl−[i]: N = 5, n = 14). *p < 0.05. Barnard’s 2 × 2 test was used to determine significance for data shown in C.
