Table 3 Association between genetic variants in pathways and serum urate in subgroups of BMI.

Subgroup	Variants	Gene	Effect allele	Underweight			Normal			Overweight
Subgroup	Variants	Gene	Effect allele	β	P	P _FDR	β	P	P _FDR	β	P	P _FDR
BMI	SNP
	rs2728121	PKD2	C	−13.03	0.636	0.954	−10.98	1.29E-04	1.16E-03	−9.49	3.46E-03	0.016
	rs13129697	SLC2A9	T	21.05	0.235	0.424	8.98	0.034	0.061	12.82	2.98E-05	2.68E-04
	rs2242206	SLC16A9	G	−17.47	0.202	0.455	1.38	0.793	0.793	1.17	0.562	0.722
	rs1165165	SLC17A3	T	24.86	0.062	0.561	11.08	0.015	0.044	8.96	0.051	0.152
	rs3759053	SLC22A11	T	−9.15	0.666	0.856	11.46	0.139	0.209	4.08	0.307	0.553
	rs1165196	SLC17A1	G	−24.38	0.096	0.287	−11.65	3.20E-03	0.014	−3.05	0.449	0.673
	rs11754288	SLC17A4	A	−28.94	0.089	0.400	−9.99	0.016	0.035	−2.18	0.712	0.712
	rs1395	SLC5A6	G	1.26	0.990	0.990	−2.48	0.546	0.702	6.86	0.160	0.360
	rs2071299	SLC17A2	G	−1.79	0.865	0.973	−0.52	0.784	0.882	2.33	0.613	0.690
	Pathway
	GO:0015075				0.990	0.990		0.009	0.018		2.15E-03	2.15E-03
	GO:0015291				0.898	1.000		0.115	0.115		2.15E-03	2.15E-03

Subgroup of BMI: 1, Underweight (BMI < 18.5); 2, Normal (18.5 ≦ BMI < 25); 3, Overweight (BMI ≧ 25). β values for SNP in serum urate were calculated by linear regression adjusted age and gender. P values for SNP in serum urate were calculated by deviance analysis for linear regression adjusted age and gender. P values for pathway were calculated by Simes test. P_FDR values for SNPs and pathways were multiple corrected by FDR method.

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