Figure 5
From: Biological and mechanical interplay at the Macro- and Microscales Modulates the Cell-Niche Fate
Young’s modulus distribution model-fitting. Native tissue (a) and decellularized pcECM (b) representing raw data fitting results. In each case, the best three fitting models are shown ranked using the Akaike information criterion (AIC), χ2 goodness of fit and adjusted R2 values (OriginPro 2015 16 bit Sr2 b9.2.272, OriginLab Corporation, Northampton, MA). Successful fit was considered as having the minimal AIC value with a χ2 < 0.05 and adjusted R2 > 0.95. Among all models tested, the exponentially modified Gauss model (GaussMod) was found to provide the optimal fit for all samples and was, therefore, used for subsequent data analyses and interpretation. GaussMod Fitted functions (representative native and pcECM are shown one next to the other as indicated in (c) were subsequently used for derivation of descriptive statistics and all analyses and comparisons made.
