Table 2 Functional annotation clustering of genes differentially expressed in IPF-F as they adapt to the in vitro environment.

From: Global Gene Expression Analysis in an in vitro Fibroblast Model of Idiopathic Pulmonary Fibrosis Reveals Potential Role for CXCL14/CXCR4

Annotation cluster

Gene Ontology (GO) Term Summary

Enrichment Score

Gene Count

P Value

1

Mitochondrion

4.91

161

1.40E-08

2

Proteolysis

4.66

137

1.70E-03

3

ER-Golgi Transport

4.62

31

1.54E-05

4

ER

4.15

131

1.69E-02

5

Membrane-enclosed lumen

3.94

233

7.09E-06

6

tRNA processing

3.41

38

1.60E-04

  1. Functional annotation analysis reveals significant mitochondria involvement in IPF-F adaptation to the in vitro environment. Summary of the most significant functional categories altered in the IPF-F as they transition into the in vitro environment (Enrichment score greater than 3.0). Fold change and annotations for the highest clusters are found in Tables S4 and S5.
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