Figure 6 | Scientific Reports

Figure 6

From: Development of an Injectable Slow-Release Metformin Formulation and Evaluation of Its Potential Antitumor Effects

Figure 6The alternative text for this image may have been generated using AI.

Metformin gel formulation induces apoptosis activation in mice tumors. (A) Representative Western blots of extracts from MDA-MB-231 tumors developed in untreated control mice (CTR), in mice treated with metformin aqueous solution (MH Sol) or metformin-loaded gel (MH Gel), using the antibody against the active fragment of caspase-3 (Cleaved caspase-3). Blots were stripped and reprobed with anti-α-tubulin antibody to normalize for differences in protein loading. (B) Densitometric analysis of Cleaved caspase-3 bands. Data presented as mean ± S.E.M from independently prepared tumor lysates (ANOVA with Dunnett’s post-hoc test: n.s. = not significant, *p < 0.05).

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