Figure 8
From: Conditional knockout of NaV1.6 in adult mice ameliorates neuropathic pain
Schematic illustration of myelinated axons in intact nerve and regenerating myelinated axons within the neuroma. In intact sciatic nerve (the Tibial nerve in the SNI model), NaV1.6 is clustered at nodes of Ranvier with KV1.1 and KV1.2 present at juxta-paranodal regions. Regenerating myelinated axons within the neuroma show higher density of nodes of Ranvier with NaV1.6 as the only NaV isoform present at these nodes, and are characterized by elongated nodal length and smaller fiber caliber and loss of KV1.1 or KV1.2 at juxta-paranodal regions. The increased nodal density with the accumulation of NaV1.6 at these nodes and the loss of KV1.1 and KV1.2 at the juxta-paranodes, and the shorter intermodal distance increase the probability of secure conduction of action potentials that are initiated in the injured fibers and the probability of burst and spontaneous firing, contributing to hyperexcitability of DRG neurons and mechanical allodynia.
