Figure 1
From: Significance of risk polymorphisms for depression depends on stress exposure
Relevance of genetic factors with respect to multiple depression-related phenotype in persons with low, moderate or high exposure to recent negative life events (RLE). Possible dependency relationship models of genetic variables were investigated for each RLE subgroup. Then, relying on Bayesian model averaging an individual posterior probability score was computed for each genetic factor. Results indicate that these genetic factors are relevant to depression only in subjects with moderate or severe RLE exposure. In addition, several factors such as BDNF, GAL-R2, HTR1A, and P2RX7 appear more relevant with respect to depression in moderate and severe RLE subgroups than the highly investigated serotonin transporter related 5-HTTLPR. Posterior probabilities of >0.50 indicate strong relevance and are marked with bold numbers.
