Table 2 Comparison of GLM models indicating the importance of gene-environment interactions. Three GLM models were constructed (see Fig. 1 for an illustration of included dependency relationships): (1) Model-1 containing only main effect of the environmental factor (relationship ‘a’), and (2) Model-2 containing only main effects of the environmental and genetic factors (‘a’ + ‘b’), and (3) Model-3 containing main effects plus interactions of the environmental and genetic factors (‘a’ + ‘b’ + ‘c’). Note that the inclusion of gene-environment interaction in Model-3 provides a significantly better model compared to Model-2 containing only main effects.
From: Significance of risk polymorphisms for depression depends on stress exposure
Compared Models | DF-1 | DF-2 | F | p-value | Variance explained | ||
|---|---|---|---|---|---|---|---|
Model 1 (‘a’) RLE | Model 2 (‘a’ + ‘b’) RLE + genetic factors (only main effects) | 4 | 18 | 1.55 | 0.086 | Model 1 6.13% | Model 2 7.03% |
Model 1(‘a’) RLE | Model 3 (‘a’ + ‘b’ + ‘c’) RLE + genetic factors (main effects + interactions) | 4 | 38 | 1.88 | 0.002 | Model 1 6.13% | Model 2 8.68% |
