Figure 3
From: Comprehensive renoprotective effects of ipragliflozin on early diabetic nephropathy in mice
Effects of the ipragliflozin treatment on molecular changes in db/db mice. (a) qRT-PCR of SLC34a1, Megalin, SGLT1, and SGLT2 for tubular markers, KIM-1 and NGAL for tubular injury, and collagen IV and fibronectin for tissue fibrosis. (b) Immunostaining for type IV collagen revealed no significant differences among the study groups. Data show the means ± SD, *p < 0.05 vs db/db (−), Bar = 50 μm in (b). n = 4–5 mice in each group, one-way ANOVA, Tukey’s multiple comparison.
