Table 3 Stratified analyses of the associations between Hcy and stroke in patients with hypertension. Abbreviations: Hcy, homocysteine; BMI, body mass index; FPG, fasting plasma glucose; SBP, systolic blood pressure; DBP, diastolic blood pressure; TG, triglycerides. Adjusted for age, sex, body mass index, systolic blood pressure, diastolic blood pressure, fasting plasma glucose, total cholesterol, triacylglycerols, high-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, serum creatinine, estimated glomerular filtration rate, and history of smoking, alcohol intake, diabetes mellitus, and hyperlipidemia.

From: Association between homocysteine and conventional predisposing factors on risk of stroke in patients with hypertension

 

Log Hcy

P for Trend

P for Interaction

<1.09 (n = 735)

1.09–1.23 (n = 813)

>1.23 (n = 710)

Sex

    

0.001

   Male, n = 1386

1

1.064 (0.751–1.506)

1.637 (1.150–2.330)

0.007

 

   Female, n = 872

1

1.268 (0.872–1.843)

2.389 (1.441–3.962)

0.003

 

Age, years

    

0.537

    ≤ 44, n = 91

1

9.489 (1.132–79.524)

4.538 (0.740–27.848)

0.089

 

   45–59, n = 812

1

1.100 (0.720–1.679)

1.577 (0.970–2.564)

0.170

 

   60–74, n = 1275

1

1.133 (0.813–1.580)

2.021 (1.407–2.904)

<0.001

 

   ≥75, n = 80

1

0.237 (0.020–2.864)

0.812 (0.063–10.492)

0.365

 

BMI, kg/m2

    

0.613

   <24, n = 967

1

1.195 (0.806–1.772)

1.873 (1.198–2.927)

0.020

 

   24–27.9, n = 938

1

1.217 (0.814–1.819)

2.193 (1.411–3.408)

0.001

 

   ≥28, n = 353

1

1.048 (0.560–1.962)

1.486 (0.757–2.916)

0.447

 

FPG, mmol/L

    

0.379

   <6.1, n = 1385

1

1.318 (0.969–1.794)

2.217 (1.565–3.140)

<0.001

 

   6.1–6.9, n = 384

1

1.164 (0.597–2.270)

1.148 (0.587–2.242)

0.888

 

   ≥7.0, n = 489

1

0.924 (0.495–1.724)

2.370 (1.130–4.971)

0.027

 

SBP, mmHg

    

<0.001

   <140, n = 517

1

1.182 (0.736–1.898)

1.852 (1.100–3.120)

0.056

 

   140–159, n = 746

1

1.153 (0.773–1.720)

1.754 (1.144–2.691)

0.027

 

   160–179, n = 514

1

1.866 (0.968–3.596)

2.659 (1.289–5.488)

0.026

 

   ≥180, n = 481

1

1.276 (0.504–3.231)

6.909 (1.370–34.840)

0.063

 

DBP, mmHg

    

<0.001

   <90, n = 862

1

1.118 (0.778–1.605)

1.675 (1.125–2.495)

0.028

 

   90–99, n = 644

1

1.339 (0.837–2.144)

2.174 (1.286–3.675)

0.014

 

   100–109, n = 450

1

1.548 (0.797–3.007)

3.970 (1.697–9.288)

0.006

 

   ≥110, n = 302

1

1.595 (0.399–6.388)

4.256 (0.693–26.137)

0.292

 

TG, mg/dL

    

0.671

   <150, n = 1208

1

1.340 (0.939–1.912)

2.346 (1.584–3.475)

<0.001

 

   150–199, n = 455

1

0.778 (0.436–1.388)

1.301 (0.675–2.510)

0.219

 

   ≥200, n = 595

1

1.121 (0.681–1.844)

1.637 (0.951–2.817)

0.165

 

Non-HDL-C, mg/dL

    

0.807

   <160, n = 1346

1

1.244 (0.891–1.737)

1.947 (1.348–2.812)

0.001

 

   160–189, n = 584

1

1.120 (0.672–1.868)

1.973 (1.132–3.439)

0.039

 

   ≥190, n = 328

1

1.291 (0.660–2.526)

2.056 (0.935–4.521)

0.195

 
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