Figure 8
Treatment with CLCF1 or VLDL efficiently decreased oxygen-induced pathological neovascularization. C57BL/6 WT mice were subjected to OIR and injected intravitreally at P12 with CLCF1 (intravitral concentration 100 ng/mL), VLDL (intravitral concentration 10 μg/mL), a combination of CLCF1 and VLDL or vehicle. Results are expressed as percentage of (A) vaso-obliterated or (B) neovascular area versus the whole retinal area. Histograms bars represent mean value of percentage, and dots represent individual values ± SEM. (C) Representative retinal flatmount images are shown in with vaso-obliterated areas delimited with dotted line. (D) Representative retinal flatmount images are shown with pre-retinal neovascularization outlined. Scale bars: 500 µm.
