Table 2 Subset of significant phenes resulting from feature selection after multiple-testing correction (supplemental Table S3) using CART in a cross validation scheme. Column Phene provides a short definition (for interpretation of the phene names see table panel B), which together with the operator OP and the threshold THR defines the model for classifying patients as tumor non-progression (distances are given in µm). ACC provides the cross-validated accuracy and NUM represents the frequency each phene candidate has been selected by the CART classifier over all cross validation folds. For interpretation of the phene names see Table 3.
From: Tissue Phenomics for prognostic biomarker discovery in low- and intermediate-risk prostate cancer
Model: tumor non-progression if | ACC | P-VAL | NUM | |||
|---|---|---|---|---|---|---|
Phene | OP | THR | ||||
1 | RATIO #CD8_border1 TO #CD34_border1 | >= | 0.10 | 0.83 | 3.05e-007 | 86 |
2 | DIST CD68 TO CD34 IN nonIntact | >= | 75.70 | 0.82 | 2.89e-008 | 90 |
3 | CORR Haralick on intact & non-intact glands | < | 0.09 | 0.82 | 4.68e-006 | 85 |
4 | RATIO #CD8_nonIntact TO #CD163_nonIntact | >= | 0.40 | 0.74 | 0.00021 | 4 |
5 | DIST CD3 TO CD8 IN border2 | < | 99.45 | 0.73 | 9.71e-005 | 2 |
6 | RATIO #CD68_border2 TO #CD34_border1 | >= | 0.04 | 0.76 | 1.84e-005 | 1 |
7 | DIST CD3 TO CD8 IN innerBorder | < | 98.69 | 0.74 | 0.00047 | 1 |
8 | RATIO #CD8_ws TO #CD3_ws | >= | 0.73 | 0.72 | 7.80e-005 | 1 |
