Figure 7
From: Purkinje cell BKchannel ablation induces abnormal rhythm in deep cerebellar nuclei and prevents LTD
Activation of the DCN neurons by the stimulation of the inferior olive nucleus. (a) Superimposition of the firing discharge of a DCN neuron during the stimulation (n = 54) of the inferior olive in a WT mouse. Note that the spikes are superimposed on a negative field potential occurring at about 3 ms. (b) Latency histogram of the negative peak recorded in WT (white areas) and in PC-BK−/− mice (gray areas). (c) Another example of DCN neurons activated by the inferior olive stimulation (n = 5) (IO stim.) but for which the negative field is less marked than in A allowing a better identification of the early spike responses. (d) Raster histogram of the DCN neuron illustrated in (c). (e) Histogram of the spike evoked responses produce by the stimulation of the inferior olive showing 4 successive activation sequences (1, 2, 3, 4) followed by a delayed inhibition (inh.).
