Table 1 Hydroxyproline content, sirius red staining, collagen type I and α-SMA in different groups. Values represent means ± SD (n = 6 each group). *p < 0.05 versus control group, #p < 0.05 versus CCl4 group, &p < 0.05 versus CCl4 plus TSA-concurrent group. CCl4 = carbon tetrachloride; TSA = trichostatin A; DMSO = dimethyl sulfoxide.

From: Trichostatin A inhibits the activation of Hepatic stellate cells by Increasing C/EBP-α Acetylation in vivo and in vitro

Groups

Hydroxyproline content (μg/mg)

Sirius red staining (%)

Collagen type I positive area (%)

α-SMA positive area (%)

Control group

0.03 ± 0.007

0.53 ± 0.18

1.1 ± 0.06

1.1 ± 0.17

CCl4 group

0.15 ± 0.027*

3.84 ± 0.48*

6.56 ± 0.47*

6.68 ± 0.4*

CCl4 plus TSA-concurrent group

0.09 ± 0.007*#

1.34 ± 0.28*#

2.45 ± 0.4*#

2.68 ± 0.28*#

CCl4 plus TSA-late group

0.11 ± 0.006*

1.47 ± 0.41*#

3.1 ± 0.43*#

3.34 ± 0.35*#&

CCl4 plus DMSO group

0.17 ± 0.048*

3.6 ± 0.55*

6.56 ± 0.83*

6.18 ± 0.54*

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