Table 1 Characteristics of patients and His.

From: Intolerable side effects during propranolol therapy for infantile hemangioma: frequency, risk factors and management

Characteristics

Total patients

Patients’ reported intolerable side effects

Patients

Gender

  Male

318 (25.2)

7 (26.9)

  Female

942 (74.8)

19 (73.1)

Gestational age

  Term born (≥37 w)

1034 (82.1)

18 (69.2)

  Born prematurely (<37 w)

226 (17.9)

8 (30.8)

Age when starting propranolol treatment (d)

96 (68–155)

60 (49–77)

Body weight when starting propranolol treatment (kg)

6.4 (5.9–6.8)

5.7 (5.2–6.1)

Duration of propranolol treatment (d)

337 (249–423)

50 (18–85)

IHs

Location†#

  Head, face and neck

668 (53.0)

14 (53.8)

  Extremity

211 (16.7)

4 (15.4)

  Trunk

326 (25.9)

7 (26.9)

  Perineal

45 (3.6)

1 (3.8)

  Internal

10 (0.8)

0 (0)

Morphologic subtype

  Localized

882 (70.0)

18 (69.2)

  Segmental

125 (9.9)

3 (11.5)

  Indeterminate

201 (16.0)

4 (15.4)

  Multifocal

52 (4.1)

1 (3.8)

Description†#

  Superficial

190 (15.1)

4 (15.4)

  Mixed

943 (74.8)

20 (76.9)

  Deep

127 (10.1)

2 (7.7)

  1. *IHs, infantile hemangioma; d, day; w, weeks.
  2. Values are presented as a number (percentage).
  3. Values are presented as a median (interquartile range).
  4. #In multiple IHs, only the clinically most important IH (typically the largest or ulcerated IH) was documented.