Table 2 Results of whole-brain exploratory analyses.

From: Brain activations associated with fearful experience show common and distinct patterns between younger and older adults in the hippocampus and the amygdala

Cluster

Peak intensity

Region

Size (voxel)

PFWE

Z score

x

y

z

(A) Brain activation of threat-related experience

High-threat > Low-threat scenes, OA (N = 20)

945

0.000

4.8

30

−88

−10

Visual Cortex

  

4.1

18

−92

−16

Visual Cortex

  

4.0

22

−84

−16

Visual Cortex

485

0.004

4.7

−10

−70

54

Visual Cortex

  

3.8

2

−58

50

Precuneus

  

3.5

−6

−60

48

Precuneus

1283

0.000

4.3

−48

−68

−22

Visual Cortex

  

4.2

−22

−98

−14

Visual Cortex

  

4.1

−32

−92

−14

Visual Cortex

Low-threat > High-threat scenes, OA: n.s.

High-threat > Low-threat scenes, YA (N = 20)

345

0.042

4.9

28

−94

−6

Visual Cortex

1170

0.000

4.0

30

22

0

Insula

  

4.0

20

2

12

Putamen

  

3.9

40

24

12

Inferior Frontal Gyrus

Low-threat > High-threat scenes, YA: n.s.

(B) Brain activation associated with pFear

Positive correlation with pFear, all participants (N = 40)

589

0.007

4.5

−26

−6

−24

Hippocampus

  

4.4

−24

−12

−14

Hippocampus

  

4.1

−32

−18

−16

Hippocampus

443

0.022

4.0

24

−12

−20

Hippocampus

  

3.9

26

−6

−26

Hippocampus

  

3.6

42

−8

−22

Parahippocampus

Negative correlation with pFear, all participants: n.s.

Positive correlation with pFear, OA: n.s.

Negative correlation with pFear, OA: n.s.

Positive correlation with pFear, YA: n.s.

Negative correlation with pFear, YA: n.s.

(C) Brain activation associated with eFear

Positive correlation with eFear, all participants (N = 40)

1182

0.000

4.6

−32

−30

50

S1

  

3.9

−30

−50

70

Superior parietal lobe

  

3.6

−46

−30

56

S1

Negative correlation with pFear, all participants: n.s.

Positive correlation with eFear, OA (N = 20)

521

0.002

4.3

−32

−48

74

Superior parietal lobe

  

4.1

−32

−30

52

S1

  

3.7

−22

−46

66

Superior parietal lobe

Negative correlation with eFear, OA: n.s.

Positive correlation with eFear, YA: n.s.

Negative correlation with eFear, YA: n.s.

  1. S1, primary somatosensory cortex.