Figure 5
Protein expression of MBP (A–C), NF-200 (D–F), p75NTR (G–I), BDNF (J–L), GAP-43 (M–O) and caspase-3 (P–R) in the brain cortex at 3 and 8 weeks pi by western blotting. n = 5. #P < 0.05 vs. normal, *P < 0.05 vs. vehicle, &P < 0.05 vs. PMSCs. (C) At 3 weeks pi, PMSCs vs. vehicle: ES = 1.34, P < 0.0001; P + C + A vs. vehicle: ES = 1.17, P < 0.0001; P + C + A vs. PMSCs ES = 0.08, P = 0.17. At 8 weeks pi, PMSCs vs. vehicle: ES = 0.9, P < 0.0001; P + C + A vs. vehicle: ES = 0.85, P < 0.0001; P + C + A vs. PMSCs: ES = 0.05, P = 0.22. (F) At 3 weeks pi, PMSCs vs. vehicle: ES = 0.72, P < 0.0001; P + C + A vs. vehicle: ES = 0.75, P < 0.0001; P + C + A vs. PMSCs: ES = 0.13, P = 0.047. At 8 weeks pi, PMSCs vs. vehicle: ES = 0.75, P < 0.0001; P + C + A vs. vehicle: ES = 1.87, P < 0.0001; P + C + A vs. PMSCs: ES = 0.3, P = 0.004. (I) At 3 weeks pi, PMSCs vs. vehicle: ES = 0.31, P = 0.0009; P + C + A vs. vehicle: ES = 1.54, P < 0.0001; P + C + A vs. PMSCs: ES = 0.19, P = 0.009. At 8 weeks pi, PMSCs vs. vehicle: ES = 0.69, P < 0.0001; P + C + A vs. vehicle: ES = 0.85, P < 0.0001; P + C + A vs. PMSCs: ES = 0.03, P = 0.3. (L) At 3 weeks pi, PMSCs vs. vehicle: ES = 0.42, P < 0.0001; P + C + A vs. vehicle: ES = 0.49, P < 0.0001; P + C + A vs. PMSCs: ES = 0.03, P = 0.31. At 8 weeks pi, PMSCs vs. vehicle: ES = 1.57, P < 0.0001; P + C + A vs. vehicle: ES = 2.18, P < 0.0001; P + C + A vs. PMSCs: ES = 0.51, P < 0.0001. (O) At 3 weeks pi, PMSCs vs. vehicle: ES = 0.57, P < 0.0001; P + C + A vs. vehicle: ES = 0.68, P < 0.0001; P + C + A vs. PMSCs: ES = 0.06, P = 0.21. At 8 weeks pi, PMSCs vs. vehicle: ES = 1.18, P < 0.0001; P + C + A vs. vehicle: ES = 1.46, P < 0.0001; P + C + A vs. PMSCs: ES = 0.32, P = 0.004. (R) At 3 weeks pi, PMSCs vs. vehicle: ES = 1.34, P < 0.0001; P + C + A vs. vehicle: ES = 2.42, P < 0.0001; P + C + A vs. PMSCs: ES = 1.73, P < 0.0001. At 8 weeks pi, PMSCs vs. vehicle: ES = 3.56, P < 0.0001; P + C + A vs. vehicle: ES = 5.19, P < 0.0001; P + C + A vs. PMSCs: ES = 0.37, P = 0.04.
