Table 2 Associations between baseline hs-CRP and PVC risk: results of Cox-regression test.

From: Higher High-Sensitivity C Reactive Protein is Associated with Future Premature Ventricular Contraction: a Community Based Prospective Cohort Study

 

Quartiles of hs-CRP

P trend

Increase per SD

P value

<0.29

0.29 to 0.71

0.71 to 1.80

>1.80

Total

Subjects

15017

14908

14964

14823

   

PVC

179(1.2)

206(1.4)

224(1.5)

299(2.0)

   

Model 1

1(ref)

1.20(0.98–1.46)

1.29(1.06–1.57)

1.78(1.47–2.14)

<0.001

1.23(1.17–1.30)

<0.001

Model 2

1(ref)

1.11(0.91–1.36)

1.15(0.95–1.40)

1.46(1.21–1.77)

<0.001

1.15(1.09–1.22)

<0.001

Model 3

1(ref)

1.108(0.90–1.36)

1.14(0.94–1.40)

1.36(1.12–1.66)

0.001

1.12(1.05–1.19)

0.001

Sensitivity analysis

Model 4

1(ref)

1.13(0.92–1.39)

1.18(0.96–1.44)

1.36(1.11–1.67)

0.001

1.11(1.04–1.18)

0.001

Model 5

1(ref)

1.15(0.93–1.41)

1.19(0.97–1.46)

1.34(1.09–1.65)

0.002

1.11(1.04–1.18)

0.002

 

Quartiles of hs-CRP

P trend

Increase per SD

P value

= < 0.29

0.29–0.7

0.70–1.73

>1.73

Men

Subjects

11708

11745

11587

11660

   

PVC

142(1.2)

156(1.3)

180(1.6)

253(2.2)

   

Model 1

11708

1.14(0.91–1.44)

1.34(1.08–1.67)

1.92(1.56–2.36)

<0.001

1.26(1.19–1.34)

<0.001

Model 2

1(ref)

1.06(0.84–1.33)

1.21(0.97–1.50)

1.55(1.26–1.91)

<0.001

1.17(1.10–1.24)

<0.001

Model 3

1(ref)

1.06(0.84–1.34)

1.19(0.95–1.49)

1.45(1.16–1.80)

<0.001

1.14(1.06–1.22)

<0.001

Sensitivity analysis

Model 4

1(ref)

1.09(0.86–1.38)

1.23(0.98–1.55)

1.46(1.16–1.82)

0.001

1.14(1.06–1.22)

<0.001

Model 5

1(ref)

1.11(0.88–1.41)

1.27(1.01–1.60)

1.45(1.15–1.82)

<0.001

1.14(1.06–1.22)

<0.001

 

Quartiles of hs-CRP

P trend

Increase per SD

P value

 = < 0.28

0.28 to 0.77

0.77 to 2.10

>2.10

Women

Subjects

3510

3499

3543

3458

   

PVC

37(1.1)

47(1.3)

41(1.2)

52(1.2)

   

Model 1

1(ref)

1.26(0.82–1.93)

1.06(0.68–1.66)

1.42(0.93–2.17)

0.097

1.12(0.98–1.28)

0.097

Model 2

1(ref)

1.19(0.78–1.84)

0.97(0.62–1.52)

1.26(0.82–1.94)

0.270

1.08(0.94–1.24)

0.270

Model 3

1(ref)

1.15(0.74–1.79)

0.97(0.61–1.54)

1.12(0.71–1.79)

0.842

1.02(0.87–1.20)

0.842

Sensitivity analysis

Model 4

1(ref)

1.13(0.73–1.76)

0.97(0.61–1.53)

1.08(0.68–1.73)

0.931

0.99(0.84–1.17)

0.931

Model 5

1(ref)

1.15(0.74–1.79)

0.94(0.59–1.49)

1.03(0.65–1.67)

0.887

0.99(0.83–1.17)

0.887

  1. Model 1 unadjusted.
  2. Model 2 adjusted for age (total + gender).
  3. Model 3 adjusted for model 2 and smoking, BMI, SBP, FBG, TC, eGFR, MI, stroke, β-R inhibitor.
  4. Model 4 adjusted for model 3 and further excluded MI.
  5. Model 5 adjusted for model 3 and further excluded MI and stroke.
  6. BMI, body mass index; MI, myocardial infarction; SBP, systolic blood pressure; FBG, fasting blood glucose; TC, total cholesterol; eGFR, estimated glomerular filtration rate; PVC, premature ventricular contraction; Hs-CRP, high-sensitivity c reactive protein.
Back to article page