Table 3 Differences in the intestinal microbota between chronic alcoholic pancreatitis (CAP) and severe alcoholic hepatitis (sAH) at the genus level.

From: Characterization of intestinal microbiota in alcoholic patients with and without alcoholic hepatitis or chronic alcoholic pancreatitis

OTU

Family

Genus

Increased in

Fold increase

Relative abundance

Mann-Whitney (ACP vs sAH)

LEfSe (ACP vs sAH)

MaAsLin (ACP vs sAH)**

Phyla

ACP

sAH

p

p corr

LDA

p

p

p corr

Proteobacteria

Pasteurellaceae

Haemophilus

sAH

106.62

0.00005

0.00508

<0.01

0.00

2.74

<0.01

<0.01

<0.01

Enterobacteriaceae

Other[Klebsiella pneumoniae]*

ACP

2.06

0.00777

0.00377

0.04

0.16

2.69

0.04

  

Serratia

ACP

10.18

0.00056

0.00005

0.05

0.18

    

Moraxellaceae

Acinetobacter

ACP

1322.02

0.01322

0

0.01

0.12

3.14

0.01

  

Pseudomonadaceae

Pseudomonas

ACP

402.98

0.00403

0

0.05

0.18

    

Other

Other[Klebsiella pneumoniae]*

ACP

23.28

0.01535

0.00066

0.02

0.13

3.14

0.02

  

Alcaligenaceae

Sutterella

sAH

5.06

0.00148

0.00747

<0.01

0.01

2.78

<0.01

  

Comamonadaceae

[Aquabacterium parvum]*

ACP

62.50

0.00063

0

<0.01

0.05

2.64

<0.01

  

Campylobacteraceae

Campylobacter

sAH

51.65

0

0.00052

0.02

0.12

2.06

0.02

  

Firmicutes

Lactobacillaceae

Lactobacillus

sAH

21.99

0.00565

0.12424

<0.01

0.01

4.04

<0.01

  

Streptococcaceae

Lactococcus

sAH

8.47

0.00010

0.00086

0.04

0.17

2.23

0.04

  

Enterococcaceae

Enterococcus

ACP

17.80

0.07650

0.00430

0.01

0.12

3.82

0.01

  

Lachnospiraceae

Lachnospira

sAH

15.56

0.00046

0.00713

<0.01

0.03

2.65

<0.01

  

Anaerostipes

sAH

5.71

0.00013

0.00071

0.02

0.12

2.16

0.01

  

Roseburia

sAH

1.76

0.00487

0.00857

0.02

0.13

2.70

0.02

  

Epulopiscium

ACP

418.45

0.00418

0

0.03

0.15

2.77

0.03

  

Ruminococcaceae

Anaerotruncus

ACP

2.35

0.00067

0.00029

0.01

0.12

2.03

0.01

  

Faecalibacterium

sAH

2.23

0.01867

0.04156

0.02

0.12

3.34

0.02

  

Other[Ruminococcus albus]*

sAH

9.02

0.00053

0.00478

0.04

0.16

2.64

0.04

  

Clostridiaceae

Clostridium

sAH

1.89

0.00406

0.00767

0.03

0.15

2.58

0.03

  

SMB53

ACP

98.21

0.00098

0

0.03

0.15

2.28

0.03

  

Veillonellaceae

Dialister

sAH

12.73

0.00050

0.00636

0.02

0.13

2.74

0.02

  

Bacteroidetes

Flavobacteriaceae

Flavobacterium

ACP

16.07

0.00016

0

0.02

0.13

2.46

0.02

  

Prevotellaceae

Prevotella

sAH

3.04

0.01709

0.05193

0.03

0.15

3.53

0.03

  

[Paraprevotellaceae]

Paraprevotella

sAH

6.66

0.00014

0.00091

0.05

0.18

    

S24-7

[Muribaculum intestinale]*

sAH

12.41

0.00036

0.00451

0.03

0.15

2.61

0.04

  

Actinobacteria

Coriobacteriaceae

Atopobium

sAH

7.95

0.00008

0.00062

0.01

0.12

2.20

0.01

  

[Raoultibacter massiliensis]*

ACP

8.63

0.00512

0.00059

0.01

0.12

2.76

0.02

  

Fusobacteria

Fusobacteriaceae

Fusobacterium

sAH

5.94

0.00139

0.00824

0.05

0.18

2.89

0.04

  
  1. *Operational Taxonomic Unit (OTU) identified using BLASTN program (vBLAST + 2.6.0) from NCBI Blast against the NCBI 16 s Microbial database. Only hits with an overall sequence identity of 97% or more were considered.
  2. **Covariates: age, sex, alcohol intake, smoking status, BMI, diabetes and proton pump inhibitors use.
  3. ACP: alcoholic chronic pancreatitis, sAH: severe alcoholic hepatitis, LEfSe: LDA Effect Size, MaAsLin: Multivariate Association with Linear Models. In bold taxa with a p corr < 0.2 in MaAsLin.
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