Table 2 Association between hemoglobin level and toll-like receptor-induced cytokine response.

From: Infant anemia is associated with reduced TLR-stimulated cytokine responses and increased nasopharyngeal colonization with Moxarella catarrhalis

 

Univariate analysis

Multiviariate analysis

β (95% CI)

p

β (95% CI)

p

TLR1-2

TNF-α

0.02 (−0.09, 0.14)

0.70

0.03 (−0.08, 0.14)

0.62

IL-6

0.16 (−0.04, 0.36)

0.12

0.21 (0.005, 0.41)

0.04

IL-10

0.11 (−0.03, 0.26)

0.13

0.08 (−0.07, 0.24)

0.06

TLR3

TNF-α

−0.001 (−0.06, 0.05)

0.96

0.01 (−0.05, 0.12)

0.68

IL-6

−0.01 (−0.11, 0.09)

0.88

−0.01 (−0.11, 0.10)

0.91

IL-10

0.02 (−0.07, 0.11)

0.63

−0.02 (−0.12, 0.08)

0.69

TLR4

TNF-α

0.22 (−0.02, 0.45)

0.07

0.26 (0.02, 0.50)

0.04

IL-6

0.34 (0.003, 0.67)

0.05

0.43 (0.07, 0.78)

0.02

IL-10

0.10 (−0.05, 0.25)

0.21

0.08 (−0.09, 0.25)

0.36

TLR7-8

TNF-α

0.15 (−0.04, 0.34)

0.12

0.17 (−0.03, 0.36)

0.09

IL-6

0.10 (−0.15, 0.35)

0.45

0.20 (−0.06, 0.46)

0.13

IL-10

0.01 (−0.11, 0.13)

0.84

0.02 (−0.13, 0.16)

0.81

PHA

TNF-α

0.05 (−0.05, 0.14)

0.32

0.08 (−0.004, 0.16)

0.06

IL-6

−0.04 (−0.19, 0.11)

0.60

−0.03(−0.17, 0.11)

0.66

IL-10

−0.05 (−0.17, 0.08)

0.47

0.01 (−0.12, 0.14)

0.85

  1. Adjusted for gestational age, gender, body weight and height at 1 year, mode of delivery, breastfeeding duration, parental allergy, and maternal education.
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