Table 2 Generated dose x and fraction affected f a data of a combination of drugs A2 + B2 with synergistic behavior.

From: CISNE: An accurate description of dose-effect and synergism in combination therapies

drug A2

drug B2

drug combination A2 + B2

x

f a

x

f a

x

f a

0.625

0.992

0.625

0.988

0.625

0.999

1.25

0.964

1.25

0.951

1.25

0.998

2.5

0.923

2.5

0.924

2.5

0.911

5

0.838

5

0.828

5

0.673

10

0.648

10

0.624

10

0.365

20

0.202

20

0.263

20

0.104

40

0.107

40

0.054

40

0.037

80

0.067

80

0.020

80

0.020

160

0.058

160

0.005

160

0.018