Figure 4 | Scientific Reports

Figure 4

From: Double deletion of tetraspanins CD9 and CD81 in mice leads to a syndrome resembling accelerated aging

Figure 4

Comprehensive DNA microarray analysis of the lung. (a) Differentially expressed genes between WT (n = 4) and CD9/CD81 DKO (n = 3) lungs were analyzed using IPA, and the results shown are the top 20 categories of differentially expressed genes in DKO lungs. (Threshold: P < 0.05) (b) Differentially expressed genes in the enriched gene category “cell death” (left) and “inflammatory response” (right) are shown. The heat map indicates that genes promoting cell death or inflammatory response were upregulated in DKO lungs. Red: higher than mean value, Green: lower than mean value. (c) Molecular pathways were analyzed using KeyMolnet software. Results shown are the top 30 molecular pathways associated with genes differentially expressed in DKO lungs.

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