Figure 6 | Scientific Reports

Figure 6

From: Voriconazole-induced photocarcinogenesis is promoted by aryl hydrocarbon receptor-dependent COX-2 upregulation

Figure 6

Schematic summary of mechanisms underlying VRCZ-induced skin cancer. VRCZ metabolites plus UVA generated reactive oxygen species and resultant DNA damage of the epidermis, but did not induce substantial apoptosis in human keratinocytes (KCs). VRCZ per se stimulates aryl hydrocarbon receptor (AhR) and upregulates COX-2 in an AhR-ARNT dependent manner of the classical (genomic) pathway. AhR, aryl hydrocarbon receptor; ARNT, AhR nuclear translocator; CYP, cytochrome P450; P-VNO, photo-modified-VNO; VNO, Voriconazole N-oxide; VRCZ, voriconazole; XRE, xenobiotic responsive element.

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