Table 2 Association between baseline corrected serum calcium and the subsequent rate of kidney function decline (95%-CI).

From: Lower serum calcium is independently associated with CKD progression

 

CKD 3a (n = 9,286)

P*

CKD 3b (n = 4,190)

P*

CKD 4 (n = 1,784)

P*

CKD 5 (n = 495)

P*

Change in eGFR decline per each mg/dL higher albumin-corrected calcium (negative = extra decline)a

  Raw data

−0.098 (−0.362; 0.165)

0.46

0.515 (0.196; 0.835)

0.002

0.428 (0.085; 0.772)

0.01

0.649 (0.323; 0.975)

<0.001

  Model 1

−0.003 (−0.044; 0.038)

0.98

0.390 (0.073; 0.707)

0.02

0.328 (−0.003; 0.686)

0.07

0.683 (0.359; 1.008)

<0.001

  Model 2

−0.009 (−0.277; 0.260)

0.95

0.391 (0.074; 0.708)

0.02

0.344 (−0.015; 0.704)

0.06

0.682 (0.355; 1.009)

<0.001

  1. aIn mL/min/1.73 m2 per year.
  2. Model 1 adjusted for age, sex, blood pressure, DM, CVD, serum albumin and hemoglobin.
  3. Model 2 adjusted for covariates in model 1 plus serum phosphorus, active vitamin D therapy and calcium supplements.
  4. *P-value for difference in the change in the rate of kidney function decline with one unit higher serum calcium.
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