Figure 1
Downregulated IL-22BP expression in IMQ-induced psoriasis mice. (A) Dorsal skin thickness, erythema and scaling were scored daily and cleared to a modified PASI score. (IMQ and Sham treated mice each n = 5). (B) Representative dorsal skin of Sham- and IMQ-treated mice on day 6. (C) Quantitative RT-PCR from homogenates of dorsal skin and sdLN for the IL-22BP gene in IMQ and Sham-treated mice. Expression levels are shown relative to the housekeeping gene HPRT. (D,E) Quantitative RT-PCR from homogenates of dorsal skin and sdLN for the IL-22BP (D) and IL-22 (E) gene in IMQ-treated mice on day 4 and day 6 of disease course. For comparison the expression is shown for Sham treated mice, too. Expression levels are shown relative to the housekeeping gene HPRT.
