Figure 2 | Scientific Reports

Figure 2

From: Application of Quantitative Microstructural MR Imaging with Atlas-based Analysis for the Spinal Cord in Cervical Spondylotic Myelopathy

Figure 2The alternative text for this image may have been generated using AI.

The procedure for generating the myelin volume fraction (MVF), axon volume fraction (AVF) and g-ratio maps. Using the Spinal Cord Toolbox (SCT), diffusion MRI (dMRI) data were registered to each other and segmented in the spinal cord. The spinal cord segmented from magnetization transfer (MT)-weighted image using the SCT was registered to the spinal cord segmented from dMRI data. The MVF map generated from T1-weighted, PD-weighted and MT-weighted images using an in-house MATLAB program was registered to dMRI data using the same warping field. dMRI data of segmented spinal cord were used for NODDI analysis with MATLAB, and the generated ICVF and ISO maps were used for generating the AVF map, followed by the g-ratio map. Segmented spinal cord dMRI data were registered to the PAM 50 template using the SCT, and the template ROI was warped to each subject’s data to measure the AVF, the MVF and the g-ratio in each white matter tract.

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