Figure 4
From: Discovery of a highly selective JAK3 inhibitor for the treatment of rheumatoid arthritis
RB1 is efficacious in treating a collagen-induced arthritis model. (A) Clinical scores of CIA mice after treatment with model, Tofacitinib (30 mg/kg), and RB1 (10 mg/kg, 30 mg/kg or 100 mg/kg). Clinical scores were measured three days per time. (B) Pathological scores of the joint sections. Bars represent the mean ± S.E.M. (n = 10). *p < 0.05 and **p < 0.01 versus model. (C) H&E and safranin O-fast green staining of paraffin sections of ankle joints. Magnification = ×40.
