Figure 2
From: Structural insights into the RNA methyltransferase domain of METTL16
Interactions between METTL16_291 and SAH. The SAH-binding sites are shown for (A) METTL16_291/SAH complex (yellow sticks, PDB ID: 6b92), (B) METTL16_40–291/SAH (blue sticks, PDB ID: 2h0027) and (C) superposition of METTL16_291/SAH and METTL16_40–291/SAH. Views of SAH-binding pocket are presented in the same orientation in all panels. Black, gray and green dashed lines respectively represent noncovalent interactions via hydrogen bonds, water-mediated hydrogen bonds and hypervalent sulfur-oxygen bonds25 between SAH atoms and residues of METTL16. Water molecules are shown as red spheres. All residues forming the hydrophobic pocket (I109, V134, V160, L165 and F227) around the adenine moiety of SAH are shown together in panel C.
