Table 5 Level stratified univariate analyses in each subtype for all patients.

	Follicle Density	Germinal Center Density	Non-circular Follicles	Non-circular Germinal Center	Mantle Zone Ratio	Mφ
Sentinel vs Level I-III (all subtypes)	p = 0.001 cc = 0.105	p = 0.077 cc = 0.101	p < 0.001 cc = −0.409	p < 0.001 cc = −0.333	p = 0.78 cc = 0.101	p < 0.001 cc = −0.216
Sentinel vs Level I-III luminal-A	p = 0.083 cc = 0.203	p = 0.744 cc = 0.039	p = 0.02 cc = −0.27	p = 0.013 cc = −0.312	p = 0.449 cc = 0.089	p = 0.795 cc = 0.031
Sentinel vs Level I-III luminal-B	p = 0.451 cc = 0.08	p = 0.978 cc = −0.003	p < 0.001 cc = −0.508	p = 0.008 cc = −0.299	p = 0.679 cc = 0.044	p = 0.019 cc = −0.246
Sentinel vs Level I-III luminal-HER2	p = 0.569 cc = −0.115	p = 0.467 cc = 0.146	p = 0.004 cc = −0.531	p = 0.133 cc = −0.331	p = 0.099 cc = 0.324	p = 0.813 cc = −0.048
Sentinel vs Level I-III HER2-enriched	p = 0.609 cc = −0.129	p = 0.956 cc = −0.011	p = 0.494 cc = −0.172	p = 0.102 cc = −0.424	p = 0.702 cc = 0.097	No cortical macrophages present
Sentinel vs Level I-III triple-negative	p = 0.565 cc = 0.067	p = 0.737 cc = −0.039	p < 0.001 cc = −0.508	p < 0.001 cc = −0.475	p = 0.641 cc = −0.054	p = 0.987 cc = 0.002

Spearman Rho correlation coefficient (cc) calculation was performed for all items (p value is provided over the cc value). Follicle density and germinal center density were calculated by number of follicles or germinal centers over lymph node area; calculation of non-circular follicles and germinal centers is described in the methods part; mantle zone ratio was calculated as area ratio of each germinal center over the corresponding follicle; Mφ: cortical macrophage infiltrations as defined in the methods part.

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