Figure 3 | Scientific Reports

Figure 3

From: The Anti-Cancer Multikinase Inhibitor Sorafenib Impairs Cardiac Contractility by Reducing Phospholamban Phosphorylation and Sarcoplasmic Calcium Transients

Figure 3

Attenuated beta-adrenergic responsiveness in sorafenib (10 µM) treated cardiomyocytes exposed to isoproterenol. Representative calcium transients (above), original 2D calcium wave line-scan (below) (a), and summary data (b). n = 14–15 cells/3–5 hearts per time point. *p < 0.001 for treatment/time interaction and p < 0.005 vs. control by 2-way mixed ANOVA with Welch’s post hoc t-test.

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