Figure 3

Characteristics of the antibody reactivity against VP1 of EV71, CA16, CB3, PV1 and RV13 in the serum samples from three age groups (1–28-day, 1–12-month and 13–72-month age groups). (A) Comparison of the antibody reactivity against VP1 of EV71, CA16, CB3, PV1 and RV13 among three age groups. Each symbol represents an individual sample. The line represents the median of the samples. (B) Comparison of the median of anti-VP1 reactivity of the five assessed EVs among three age groups. Statistical significance was tested using the Nemenyi non-parametric test or one-way ANOVA analysis. * indicates p < 0.05, ** indicates p < 0.001, “NS” represents no significant difference between the two groups (p > 0.05). In the 13–72-month age group, # represents p < 0.05 between the antibody reactivity against any two VP1 from the five assessed EV VP1 proteins except two pairs: EV71 vs CA16 and CB3 vs PV1.