Table 2 HA and NA-specific IgG antibody titers in MVA-vector immunized mice.

From: Immunogenicity and Protection Against Influenza H7N3 in Mice by Modified Vaccinia Virus Ankara Vectors Expressing Influenza Virus Hemagglutinin or Neuraminidase

Immunization

Mean IgG Titer (log 10 )

Protection

H7 (#positive)

N3 (#positive)

103 MVA-HA

1.4 ± 0.8 (1/5)

N.D.a

No

103 MVA-NA

N.D.

2.4 ± 1.3 (3/5)

No

103 MVA-HA

103 MVA-NA

1.0 (0/5)b

1.8 ± 0.8 (3/5)

No

104 MVA-HA

2.4 ± 1.3 (3/5)

N.D

Yes

104 MVA-NA

N.D.

3.8 ± 0.3 (5/5)

Yes

104 MVA-HA

104 MVA-NA

2.2 ± 1.1 (3/5)

3.5 ± 0.6 (5/5)

Yes

106 MVA-HA

4.2 ± 0.1 (5/5)

N.D.

Yes

106 MVA

1.0 (0/5)

1.0 (0/5)

No

  1. aN.D. – Not done.
  2. bFor titer calculations, test samples with a titer <20 (below quantitation) were assigned a value of 10.
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