Figure 4 | Scientific Reports

Figure 4

From: An intronic mutation in Chd7 creates a cryptic splice site, causing aberrant splicing in a mouse model of CHARGE syndrome

Figure 4

Trooper mice are hearing impaired and have growth deficiencies. (A) Average ABR thresholds of Chd7+/Trooper (n = 12) and Chd7+/+ (n = 12) mice. Chd7+/Trooper thresholds were significantly elevated at 4,8 and 16 kHz in comparison to Chd7+/+ controls. *p < 0.001 based on t- tests performed with the Holm-Sidak correction for multiple comparisons. Error Bars = SEM. (B) Photograph of female Chd7+/Trooper and Chd7+/+ littermates (at 50 days of age) illustrating the reduced size and length of Chd7+/Trooper mice. Scale Bar = 3 cm. (C,D) Average weights of male and female Chd7+/+ (n = 19 female and 20 male) and Chd7+/Trooper (n = 26 female and 21 male) mice, from 3–8 weeks of age.

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