Table 1 Penetrance of Trooper pathology compared with Looper pathology.
Phenotype | Chd7 Trooper | Trooper WT | Chd7 Looper | Looper WT |
|---|---|---|---|---|
Circling | 4% | 0% | 83% | 0% |
(2/52) | (0/46) | (5/6) | (0/10) | |
Hearing impairment | 100% | 0% | 100% | 0% |
(12/12) | (0/12) | (18/18) | (0/22) | |
Semicircular Canal malformation | 100% | 0% | 100% | 0% |
(2/2) | (0/1) | (3/3) | (0/1) | |
Blepharoconjunctivitis | 12% | 0% | 69% | 0% |
(6/52) | (0/46) | (11/16) | (0/19) | |
Post Weaning Survival (of total colony population) | 53% | 47% | 41% | 59% |
(52/98) | (46/98) | (68/167) | (99/167) |
